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Many MRI steps only work if the scans are roughly aligned with the MNI template. Rotations (pitch) in particular is difficult to compensate for.

Approach: all scans get manually aligned

See Step by Step Instructions

  • Starting point

    • Scans are manually converted to nifti in the raw data folder.

    • Each scan is linked to a “study”, and this study is added to one or more projects.

  • At the project level, you can choose to manually reorient the scan to align with the template. Specifically, you can determine the 6 rigid-body parameters for the coregistration (6 parameters = x/y/z shift, and rotations about each axis).

    • The scan only needs this doing once, even if it’s in multiple projects or multiple groups in a project.

  • Those parameters are saved in the database, and they are associated with the study.

    • Rationale: One scan = one alignment. If the study is used in multiple projects, the same parameters will be reused. Additionally, if a second preprocessing is done, that will also use the same parameters.

  • CSPM will apply the parameters when the Project “Copy and Coreg” is done (before preprocess).

    • Step 1: copy from raw nifti folder to “rawimeages” project folder

    • Step 2: if parameters are associated with this scan, apply them (i.e., coreg the scan)

      • A file “coregister2mni_completed.mat” will be saved (e.g., U:\OSA2019pre\rawimages\OSA\OSA5020\T1w_MPR)E50200220191204S12\Nifti\coregister2mni_completed.mat)

  • Each scan is aligned separately. However, it’s easy to copy the same parameters between scans (useful if one subject has 10 scans with the same rotation, for example).

    • Rationale: problems arise if we assume that one subject has the same rigid-body shifts for all scans. This approach is more time-consuming, but simple and reliable.

Example of new GUI (see Step-by-Step Instructions for details)

Up to Sep 2020

T1

Gets manually aligned in project folder Legacy - Manually Aligning T1's to MNI

Failed experiment:

All other scans get T1 coreg parameters applied
Rationale was that person in scanner would have similar orientation for all scans (e.g, 30 degree pitch for T1, fMRI, DTI, etc.). This is actually not the case genreally, as various scans have various orientations, and it was only a conincidence when fMRI and T1 rotations were the same. This is now basically disabled in CSPM unless you go through several hoops.

Non-T1 scans:

Manually adjust in project rawimages nifti folders

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